Funding: Comisión Europea

Program: Instruct- European Research Infrastruture Consortium

Start date - end date: 03/02/2017 – 31/08/2019

Instruct is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to users.

Structural biology is one of the key frameworks on which we interpret molecular and cellular functions. The main experimental technologies are complementary, and increasingly link detailed atomic structure with cellular context.

Structural biology is currently in the middle of a revolution enabled by significant advances in the tools (direct electron detectors in EM, advances in synchrotron sources and detectors, XFELs, ultra-high field NMR, super-resolution cryo-light miscroscopy).

The project Novel fascin inhibitors for the treatment of colorectal serrated Adenocarcinoma (PID2428) will apply computational drug discovery methodologies in order to process the in-house library of compounds available at the infrastructures provided by CORBEL (FMP screening unit using in-house libraries (http://www.leibniz-fmp.de/core-facilities/screening-unit/screening-unit/intro.html). The project team will select and prioritize hits so the Instruct Infrastructure at the IGBMC-CERBM in Strasbourg, will characterize the bidning affinity of these compounds to fascin using thermophoresis techniques. Experimental results will be used for recalibration of the computational drug discovery methods and compounds inhibiting fascin will be considered for further and more detailed studies, using techniques such as Isothermal Titration Calorimetry. 

Area: Structural Biology

Web site: https://www.structuralbiology.eu/